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CH3403 - Medicinal Chemistry and Pharmaceutical Analysis

Credit points: 3
Year: 2019
Student Contribution Band: Band 2
Administered by: College of Science and Engineering

This subject builds upon the fundamental concepts of chemistry introduced in the first year subjects. It deals with the key chemical concepts of medicinal/pharmaceutical chemistry and pharmacology, including the mechanisms of drug action and metabolism. The subject also introduces the principles of drug stability and basic mechanism of drug degradations. The importance of chemical analysis in relation to drug development, drug testing and quality control is examined. Specific topics to be covered include instrumental methods of analysis and structure determination of active pharmaceutical ingredients (API's), particularly NMR, chromatographic separation techniques (HPLC and GLC, thermal analysis methods (DSC and TGA) and Vibrational Spectroscopic techniques (FTIR and Raman spectroscopy). Pharmaceutical case studies are also covered as well as its application in a biomedical setting.

Learning Outcomes

  • explain the principles of medicinal chemistry and pharmacology for pharmaceutical agents, including mechanisms of drug metabolism and drug stability;
  • describe and apply spectroscopic techniques used in the quality control of pharmaceuticals, in drug testing & development;
  • explain polymorphism and the analytical techniques used to differentiate them;
  • describe modern separation techniques in pharmaceutical chemistry;
  • discuss pharmaceutical application case studiesin a biomedical setting.
Assumed
Knowledge:
First year Chemistry
Prerequisites: CH1001, CH1002
Inadmissible
Subject
Combinations:
PC2002, CH2043

Availabilities

Townsville, Internal, Study Period 1
Census Date 28-Mar-2019
Workload expectations:

The student workload for this 3 credit point subject is approximately 130 hours.

  • 36 hours lectures
  • 3 hours tutorials
  • 12 hours practicals
  • 6 hours workshops/Seminars
  • assessment and self-directed study
Assessment: end of semester exam (60%); workshop assignment (10%); practicals (30%).

Note: Minor variations might occur due to the continuous Subject quality improvement process, and in case of minor variation(s) in assessment details, the Subject Outline represents the latest official information.