PC2002 - Molecular Basis of Therapeutics 3
|Student Contribution Band:
||College of Science and Engineering
Available to students enrolled in the Bachelor of Pharmacy.
This subject builds upon the fundamental concepts of chemistry introduced in the first
year of the Pharmacy program. It deals with the key chemical concepts of medicinal/pharmaceutical
chemistry and pharmacology, including the mechanisms of drug action and metabolism.
The subject also introduces the principles of drug stability and basic mechanism of
drug degradations. The importance of chemical analysis in relation to drug development,
drug testing and quality control is examined. Specific topics to be covered include
instrumental methods of analysis and structure determination of active pharmaceutical
ingredients (API's, in particular NMR, chromatographic separation techniques (HPLC
and GC), thermal analysis methods (DSC and TGA) and Vibrational Spectroscopic techniques
(FTIR and Raman spectroscopy). Approaches to the development of new pharmaceutical
agents, including pharmacognosy, rational drug design and high-throughput screening
are also introduced.
- describe and apply spectroscopic techniques used in the quality control of pharmaceuticals,
in drug testing & development;
- explain polymorphism and the analytical techniques used to differentiate them;
- describe modern purification techniques in pharmaceutical chemistry;
- explain the principles of medicinal chemistry and pharmacology for pharmaceutical
agents, including mechanisms of drug metabolism and drug stability;
- understand and solve pharmaceutical application case studies;
- employ basic synthetic techniques to synthesise model pharmaceutical and undertake
its analysis in a practical setting.
- end of semester exam (60%)
- quizzes or tests (10%)
- practicals (30%).
Special Assessment Requirements
To pass this subject you must: get an overall score of 50% or greater; score at least
50% in both the individual components (exam and practicals); complete mandatory induction
and practical sessions.
||CH1001 AND PC1005
|PP3150, CH2043, CH3403
Minor variations might occur due to the continuous Subject quality improvement process,
and in case
of minor variation(s) in assessment details, the Subject Outline represents the latest