PC2001 - Molecular Basis of Therapeutics 2
|Student Contribution Band:
||College of Public Health, Medical & Vet Sciences
Available to students enrolled in the Bachelor of Pharmacy.
This subject introduces the regulatory systems in cells and organisms which form the
basis for pharmacology. It builds on the material covered in the two 1st semester
subjects BC2013 and BC2014, by addressing how multicellular organisms can control
and integrate their metabolic processes and how cells interrelate and communicate
with each other. It also shows how disturbances in these processes cause disease and
how these pathogenic processes can be normalized by therapeutic drugs. The subject
begins with detailed descriptions of the molecular structure and function of biological
membranes. Transport across or within biomembranes is an important feature that underpins
our understanding of how proteins and drugs move between cells and within a cell.
This is the basis of regulation at the metabolic pathway level and is important in
understanding the mode of action of many drugs. The subject explores the functions
of enzymes, how they work at the molecular level and how inhibitors may interfere
with their action. Regulation at the cellular level is explored in detail, examining
how signals are communicated at the cell surface to invoke downstream intracellular
molecular events, how nerve cells communicate and how cell surface receptors interact
with agonists and antagonists. This includes examples of specific molecular ligand-receptor
interactions both clinically and those that have been exploited in drug development.
Also covered are the major cellular processes, the cell cycle and cell death. Therapeutic
and vaccine failure in modern day drug discovery & delivery is explored. This course
of lectures should therefore give you a balanced view of how cells are controlled,
how they communicate with each other and how chemical agents are able to alter cellular
- describe cell regulation mechanisms that allow cells to divide, function, move and
die in multicellular organisms;
- discuss signaling by cells using transmembrane receptors, enzymes, proteins and other
molecules to relay information between cells and how they can be inhibited;
- explain how molecules can be utilized for therapeutic and pharmaceutical means and
the experimentation and regulatory processes required before they come to market;
- demonstrate skills in scientific literature research, science communication, laboratory
and analytical skills.
||CH1001 and PC1005
|BC2024 and PP3150
Study Period 2
|Census Date 24-Aug-2017
||Professor Andreas Lopata
||Dr Sandip Kamath, Dr Anupama Bangara Kulur, Professor Alan Baxter, Mrs Rebecca Tolentino, Dr Elecia Johnston, Dr Aya Taki.
- 36 hours lectures
- 6 hours tutorials
- 24 hours practicals
||end of semester exam (60%); assignments (40%).
Minor variations might occur due to the continuous Subject quality improvement
process, and in case of
minor variation(s) in assessment details, the Subject Outline represents the latest