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PC1005 - Molecular Basis of Therapeutics 1

Credit points: 3
Year: 2019
Student Contribution Band: Band 2
Administered by: College of Science and Engineering

Available to students enrolled in the Bachelor of Pharmacy.

This subject (37 lectures) is in common with CH1002 and builds on the content of CH1001 to provide broad exposure of students to the major principles and reactions of relevance to inorganic, organic and physical chemistry. A major emphasis will continue to be the applicability of chemistry in the wider scientific context, particularly in the biological, biomedical, earth and environmental sciences. Organic Chemistry (13 lectures): General features of organic reactions, reactive intermediates and energetics. Mechanisms and applications of major reaction types: radical substitution, electrophilic addition, nucleophilic substitution at saturated carbon, nucleophilic addition and substitution at carbonyl groups. Electrophilic aromatic substitution. Stereochemistry of hydrocarbons. Spectroscopy and structure determination. Physical Chemistry (12 lectures): What controls reaction rates? Reactions, kinetics and mechanism. Electrochemistry. Fundamentals and applications in industry and nature. Phase equilibria, colligative properties and chemical partitioning applied to environmental, industrial, physiological and biological process. Atomic structure, Bonding and Periodicity (12 lectures): Applications of redox chemistry in industrial processes, an introduction to transition metal chemistry and its involvement in bioinorganic chemistry, spectroscopy with applications in analytical chemistry, and the elucidation of chemical structures.

Learning Outcomes

  • develop competence in the application of common laboratory techniques in chemistry, particularly those relevant to the measurement of drug structure and activity;
  • in conjunction with Ch1001, to provide the background in key chemical concepts and principles necessary for appropriate understanding of the pharmaceutics, medicinal chemistry and pharmacology subjects in later years of the course.
Prerequisites: CH1001


Townsville, Study Period 2, Internal
Census Date 29-Aug-2019
Coordinator: Assoc. Professor Michael Oelgemoeller
Lecturers: Dr Murray Davies, Assoc. Professor Michael Oelgemoeller, Dr Mark Barnes, Professor Peter Junk.
Workload expectations:

The student workload for this 3 credit point subject is approximately 130 hours.

  • 39 hours lectures
  • 20 hours tutorials - 2 h guided learning tutorials in weeks 3-13
  • 30 hours practicals
  • assessment and self-directed study
Assessment: end of semester exam (60%); assignments (10%); laboratory work and reports (30%).

Note: Minor variations might occur due to the continuous Subject quality improvement process, and in case of minor variation(s) in assessment details, the Subject Outline represents the latest official information.