CH1010 - Biological Chemistry for Dentistry
|Student Contribution Band:
General Chemistry revision Acid/base and organic functional group chemistry.
Natural Product Chemistry Extraction, chromatography, analysis, spectroscopy;
terpenes, steroids, alkaloids, drug discovery. Bio-organic Chemistry Structure
and function of carbohydrates, proteins and DNA; Disperse systems macromolecular
colloids, emulsions. Bio-inorganic Chemistry Coordination complexes. Hemoglobin,
metalloenzymes. Dental chemistry Enamel : mineralisation / re-mineralisation
/ fluoride, caries and carbohydrates, salivary proteins. Enzymatic Chemistry
The function of enzymes, inhibitors, cofactors, coenzymes and vitamins. Lipids
and Membranes Fatty acids, complex lipids, lipid proteins, steroids, fluid mosaic
membrane. Passive/active transport. Bioenergetics Catabolic and anabolic reactions.
The metabolic role of ATP. Fatty acid synthesis. Glucogenesis. Glycolysis and the
citric acid cycle. Electron Transport Oxidative phosphorylation. Shuttles.
DNA Processes Replication, transcription and translation. Recombinant DNA and
PCR. DNA microarrays. Oncogenes, Cancer drugs. Gene regulation. Signal transduction.
- to cover the fundaments of natural product chemistry and biochemistry / molecular
biology with special emphasis given to areas applicable to dentistry. biochemical
topics covered include structure, function and metabolism (energetic pathways and
regulation) of carbohydrates, lipids, proteins and nucleic acids;
- develop a clear understanding of the classification systems used for small organic
and large macromolecules and become conversant with how drugs are designed and characterized;
- develop practical experience in methods of molecular purification and characterisation;
- discover how functional proteins such as receptors (signal transduction), enzymes
and transporters, represent a major target for the action of pharmaceutical drug agents;
- become familiar with clinical correlates to the above such as demineralization / remineralization
/ fluorosis of enamel (Caries), blood clotting disorders, nutritional disorders, molecular
basis of cancer, diseases of lipid metabolism/ transport.
||SENIOR CHEMISTRY OR CH1020 AND SENIOR MATHSB OR MA1020
Study Period 1
|Census Date 27-Mar-2014
||Assoc. Professor Michael Liddell.
- 36 hours lectures
- 10 hours tutorials
- 30 hours practicals
- 10 hours - LearnJCU modules.
||end of semester exam (42%); quizzes or tests (38%); marks for practical exercises (20%).
|Special Assessment Requirements:
||Practical component: students will fail the course if they miss 3 or more practicals
without a valid reason (generally medical certificates will be required).
Minor variations might occur due to the continuous Subject quality improvement process,
and in case
of minor variation(s) in assessment details, the Subject Outline represents the latest