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CH1010 - Biological Chemistry for Dentistry

Credit points: 3
Year: 2012
Student Contribution Band: Band 4
Administered by: School of Pharmacy & Molecular Sciences

General Chemistry revision Acid/base and organic functional group chemistry. Natural Product Chemistry Extraction, chromatography, analysis, spectroscopy; terpenes, steroids, alkaloids, drug discovery. Bio-organic Chemistry Structure and function of carbohydrates, proteins and DNA; Disperse systems macromolecular colloids, emulsions. Bio-inorganic Chemistry Coordination complexes. Hemoglobin, metalloenzymes. Dental chemistry Enamel : mineralisation / re-mineralisation / fluoride, caries and carbohydrates, salivary proteins. Enzymatic Chemistry The function of enzymes, inhibitors, cofactors, coenzymes and vitamins. Lipids and Membranes Fatty acids, complex lipids, lipid proteins, steroids, fluid mosaic membrane. Passive/active transport. Bioenergetics Catabolic and anabolic reactions. The metabolic role of ATP. Fatty acid synthesis. Glucogenesis. Glycolysis and the citric acid cycle. Electron Transport Oxidative phosphorylation. Shuttles. DNA Processes Replication, transcription and translation. Recombinant DNA and PCR. DNA microarrays. Oncogenes, Cancer drugs. Gene regulation. Signal transduction.

Learning Outcomes

  • to cover the fundaments of natural product chemistry and biochemistry / molecular biology with special emphasis given to areas applicable to dentistry. biochemical topics covered include structure, function and metabolism (energetic pathways and regulation) of carbohydrates, lipids, proteins and nucleic acids;
  • develop a clear understanding of the classification systems used for small organic and large macromolecules and become conversant with how drugs are designed and characterized;
  • develop practical experience in methods of molecular purification and characterisation;
  • discover how functional proteins such as receptors (signal transduction), enzymes and transporters, represent a major target for the action of pharmaceutical drug agents;
  • become familiar with clinical correlates to the above such as demineralization / remineralization / fluorosis of enamel (Caries), blood clotting disorders, nutritional disorders, molecular basis of cancer, diseases of lipid metabolism/ transport.

Graduate Qualities

  • The ability to think critically, to analyse and evaluate claims, evidence and arguments;
  • The ability to define and to solve problems in at least one discipline area;
  • The ability to lead, manage and contribute effectively to teams;
  • The ability to speak and write logically, clearly and creatively;
  • The ability to access and employ online technologies effectively.


Cairns, Study Period 1, Internal
Census Date 22-Mar-2012
Coord/Lect: Assoc. Professor Michael Liddell.
Workload expectations:
  • 36 hours lectures
  • 10 hours tutorials
  • 30 hours practicals
  • 10 hours - LearnJCU modules.
Assessment: end of semester exam (42%); quizzes or tests (38%); marks for practical exercises (20%).
Special Assessment Requirements: Practical component: students will fail the course if they miss 3 or more practicals without a valid reason (generally medical certificates will be required).

Note: Minor variations might occur due to the continuous Subject quality improvement process, and in case of minor variation(s) in assessment details, the Subject Outline represents the latest official information.